By Chen M.
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48. Doig CJ, Sutherland LR, Sandham 10, et al: Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients. Am J Respir Crit Care Med 1998;158:444-451. 49. Kollef MH, Eisenberg PR: A rapid qualitative assay to detect circulating endotoxin can predict the development of multiple organ dysfunction. Chest 1997;112:173-180. 50. Deitch EA, Sambol JT: The gut-origin hypothesis of multiple organ dysfunction syndrome. In Deitch EA, Windson A, Vincent JL (eds): Sepsis and Multiple Organ Dysfunction.
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The guanine-cytosine content varies from 50% to 55%. Small amounts of the base, 5-methyicytosine, as well as methylated derivatives of the other bases can also be found. The chain of nucleotides that is DNA, is formed by joining the bases through phosphodiester bonds using ribose as the common linkage. The phosphodiester linkage is between the 5'-phosphate group of one nucleotide and the 3'-OHgroup of the adjacent nucleotide. This provides a direction (5' to 3') to the chain. A typical segment of the chain is illustrated in Figure 4-1.
A nonparametric procedure associated with a clinically meaningful efficacy measure (2000)(en)(6s) by Chen M.