By Andrew Eisen, Charles Krieger
Amyotrophic Lateral Sclerosis, in a different way referred to as Lou Gehrig's sickness, is among the many degenerative ailments of the getting older worried approach. this article well synthesizes the hot explosion of study into this actual situation to build an in depth and finished evaluate. Drs. Eisen and Krieger convey their study services and vast scientific adventure to supply this functional and thought-provoking account. Chapters disguise the epidemiology, molecular biology, and pathophysiology of ALS, in addition to matters pertinent to medical evaluation and care.
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Extra resources for Amyotrophic Lateral Sclerosis: A Synthesis of Research and Clinical Practice
1 years. 5 years respectively). 7 shows the second-order exponential relationship, for men and women, which best fitted the data relating onset age and disease duration. It also shows the 75th and 95th upper prediction bounds on disease duration at each age, and the corresponding life expectancy for the population of British Columbia for the years 1993-1995. 7. Kaplan-Meier survival curves by sex (top) and age (bottom). The survival curves are not significantly different for men and women. Age has a significant effect on survival of ALS, with patients who have a young onset living longer.
The peak incidence for women was 61 per 100000 and occurred between 1956 and 1958. Since then, there has been a steady decline in the incidence for both men and women. The present incidence is similar to that of the rest of the world. (From Zhang et al. (1996). Ada Neurologica Scandinavica, 94; 19. ) ALS-PD of Guam was the result of toxic ingestion of the cycad plant (Cycas circinalis, false sago plant) (O'Gara, Brown and Whiting, 1964). Before westernization, and with it the construction of large military bases after the Second World War and urbanization of the local island communities, 'fadan' was a staple in the Chamorro diet.
001) (Fig. 6). These data might imply a transmittable agent which is more readily expressed in northern climates. It could also be that populations living in northern latitudes have a lifestyle that renders them more susceptible to a toxin(s) which may be of importance in developing ALS. The issue of geographic variation in ALS incidence is worthy of further investigation. If such a relationship can befirmlyestablished, it would support an environmental role in ALS, or a role of different geographic racial groups, some with a greater abundance of susceptibility genes for ALS.
Amyotrophic Lateral Sclerosis: A Synthesis of Research and Clinical Practice by Andrew Eisen, Charles Krieger