Edward S. Meek M D, Ch B, MRC Path (auth.)'s Antitumour and Antiviral Substances of Natural Origin PDF

By Edward S. Meek M D, Ch B, MRC Path (auth.)

ISBN-10: 3642462367

ISBN-13: 9783642462368

ISBN-10: 3642462383

ISBN-13: 9783642462382

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ODA (1963) reported suppression of the growth of vaccinia, but felt that this might result from inhibition of penetration of the cell by the virions. lg/ml, however, the penetration of poliovirus into cells was not interfered with; but at these concentrations the growth of Mengo encephalomyelitis virus was not suppressed (REICH and FRANKLIN, 1961). , 1961). Mycoplasma SOMERSON and COOK (1965) found that the growth of Rous sarcoma virus was suppressed in vitro by the presence of Mycoplasma orale in the culture.

An attempt has been made by WEBB et al. (1966) recently to treat 28 cases of leukaemia and other neoplasms with two types of arbovirus (LANG AT and KYASANUR Vivomycin and Borrelidin 31 FOREST). None of these were cured but four benefitted to some extent from the treatment. WEBB et a!. (1966) consider three mechanisms which might account for the effects. a) direct oncolysis, b) interference with an oncogenic virus and induction of interferon, c) enhancement of the antigenicity of cancer cells. ZAKAy-RONESS and BERNKOPF (1964) studied the effect of injections of vaccinia virus (both active and irradiated by ultraviolet light) in rats 11 days after inoculation of Shay leukaemia cells.

They are often used with radiotherapy to decrease radiation oedema. HALL (1966) reported that high dosage corticoid therapy is effective in the treatment of Hodgkin's disease. Published information on the mechanism of action of the steroid hormones has been reviewed by WILLIAMS-AsHMAN (1965). , 1963) on the activation and suppression of genes in the control of protein synthesis, it has been suggested that hormones may play a direct part in the methanism. However, HECHTER and HALKERSTON (1964), reviewing the evidence available, think it unlikely that hormones act directly on genes.

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Antitumour and Antiviral Substances of Natural Origin by Edward S. Meek M D, Ch B, MRC Path (auth.)


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