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Noninvasive detection of tumor hypoxia using the 2-nitroimidazole [18F]EF1. J Nucl Med 2000;41: 327–36. [66] Evans SM, Hahn SM, Magarelli DP, et al. Hypoxia in human intraperitoneal and extremity sarcomas. Int J Radiat Oncol Biol Phys 2001;49: 587–96. [67] Evans SM, Hahn S, Pook DR, et al. Detection of hypoxia in human squamous cell carcinoma by EF5 binding. Cancer Res 2000;60:2018–24. [68] Dolbier Jr WR, Li AR, Koch CJ, et al. [18F]-EF5, a marker for PET detection of hypoxia: synthesis of precursor and a new fluorination procedure.

The imaging sequence was as follows: 13 2-minute frames started 2 minutes after injection, 2 3-minute frames started 40 minutes after injection, and 1 3-minute frame started 75 minutes after injection. Thirteen knees in 9 patients displayed a typical visual pattern of synovitis and were used for the SUV analysis. In most knees, the uptake reached a plateau 16 minutes after injection, and in 4 knees, the peak activity was observed on the first frame 2 minutes after injection. It then slightly decreased until the 10th minute after injection.

Adding further complexity to the diagnosis of osteomyelitis is the fact that acute neurodegenerative osteoarthropathy, also known as Charcot joint, can present with signs, symptoms, and findings similar to those of infections [10]. There are currently two theories proposed to describe the pathophysiology of Charcot joint. According to the neurotraumatic theory, neuropathy leads to diminished proprioception which, in combination with repetitive trauma, results in bone and joint destruction. In the neurovascular theory, it is postulated that an autonomically mediated vascular reflex results in hyperemia and periarticular osteopenia.

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[Article] Robust modeling in screening studies estimation of sensitivity and preclinical sojourn time distribution by Shen Y.

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