Download e-book for kindle: Atypical Parkinsonian Disorders: Clinical and Research by Irene Litvan

By Irene Litvan

ISBN-10: 1588293319

ISBN-13: 9781588293312

ISBN-10: 159259834X

ISBN-13: 9781592598342

Autoimmune problems of the outside stay an enigma for plenty of clinicians and scientists now not accustomed to those normally critical and persistent ailments. The booklet offers an summary and the most recent info at the huge spectrum of cutaneous autoimmune issues for clinicians, scientists and practitioners in dermatology, medication, rheumatology, ENT, pediatrics and ophthalmology. The booklet is exclusive because it offers the state of the art wisdom on pathophysiology, scientific analysis and administration of those problems supplied by means of the realm specialists within the box. the first goal is to expand the knowledge of the pathophysiology of cutaneous autoimmune issues and to supply a pragmatic consultant to find out how to determine and deal with those stipulations. The booklet is illustrated with many tables, illustrative figures and scientific colour pictures. the second one variation has been prolonged by way of chapters on autoimmune pigmentary issues (vitiligo), hairloss (alopecia areata) and cutaneous indicators of rheumatic problems.

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Additional resources for Atypical Parkinsonian Disorders: Clinical and Research Aspects

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Interestingly, there is little difference between the estimates for these different studies. Perhaps more surprising is that studies that have screened a whole population (9,10) did not find higher rates than those using existing medical records or other databases. It is well recognized in the Parkinson’s disease (PD) literature that a proportion of PD cases will be detected de novo by the screening procedure, though this varies across European centers (17). It is possible that this “clinical iceberg” phenomenon is less important for PSP and MSA because their symptoms and disease progression make them less likely to be undetected.

It also raises questions as to the pathological substrate for dementia in DLB patients. Although some studies have shown a correlation between the numbers of cortical LBs and cognitive dysfunction (38–41), others have not (29). This suggests that coexisting AD pathology, Lewy neurites, and/or degeneration of specific neuronal populations could all contribute to dementia, possibly in an additive fashion (42,43). THE SPECTRUM OF LB DISORDERS There is striking clinical and pathological overlap between PD and DLB.

Almost all the studies except that from Nath and colleagues (15) estimate rates based on 11 or fewer cases, which demonstrates the problem with studying rare neurological disorders. Some studies have specifically aimed to detect cases of PSP and/or MSA whereas others have been generic prevalence studies for parkinsonism. Interestingly, there is little difference between the estimates for these different studies. Perhaps more surprising is that studies that have screened a whole population (9,10) did not find higher rates than those using existing medical records or other databases.

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Atypical Parkinsonian Disorders: Clinical and Research Aspects by Irene Litvan


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