By John Caldwell
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Extra info for Biological Basis of Detoxication
A benzo[a]pyrene-7,8-dihydrodiol-9,10epoxide is the major metabolite involved in the binding of benzoli/]pyrene to DNA in isolated viable rat hepatocytes. -Biol. Interact. 29, 117-127. 134. Slaga, T. , and Boutwell, R. , eds. (1978). "Mechanisms of Tumor Promotion and Carcinogenesis," Vol. 2. Raven Press, New York. 135. , McDonald, T. , Jerina, D. , Wood, A. , and Conney, A. H. (1977). Epidermal hyperplasia after topical application of benzoU/]pyrene, benzoli/]pyrene diol epoxides, and other metabolites.
REGIOSELECTIVITY AND STEREOSELECTIVITY OF CYTOCHROME P-450 A. 1), have been purified from both rat and rabbit liver microsomes. 43,44 Indeed, the purification of eight distinct forms of cytochrome P-450 from uninduced rabbit liver microsomes has been reported. 45 The relative concentrations of these forms can be dramatically altered by exposure in vivo to inducers such as phenobarbital, stilbene oxide, pregnenolone 16-carbonitrile, ethanol, isosafrole, and poly cyclic aromatic compounds that also increase total cytochrome P-450 levels.
A. 73, 607-611. , Wislocki, P. , Jerina, D. , and Conney, A. H. (1978). Tumorigenicity studies with diol-epoxides of benzo[a]pyrene indicate that (±)-ira^5-7j8,8o:-dihydroxy-9a,10a-epoxy-7,8,9,10-tetrahydrobenzo[«]pyrene is an ultimate carcinogen in newborn mice. Cancer Res. 38, 354-358. Conney, A. , Wood, A. , Lehr, R. , and Jerina, D. M. (1978). Biological activity of polycyclic hydrocarbon metabolites and the bay region theory. Adv. Pharmacol. Ther. 9, 41-52. Wood, A. , Chang, R. , Thakker, D.
Biological Basis of Detoxication by John Caldwell